The series follows Larry in his life as a semi-retired television writer and producer in Los Angeles and later New York City.
In many episodes, Curb—like its predecessor Seinfeld—tied together apparently unrelated events woven throughout a given episode into an unforced climax that resolves the story lines simultaneously, either to Larry's advantage or detriment.
While each episode has a distinct individual plot, most seasons feature a story arc that extends across several episodes throughout the season and culminates in a season finale that often features the return of many of the characters that appeared throughout the season.
Among the show's many recurring roles, Richard Lewis, Ted Danson, and Wanda Sykes play fictionalized versions of themselves as old friends of Larry's with whom he frequently butts heads. Bob Einstein frequently appears as Marty Funkhouser, another of Larry's oldest friends. Loretta eventually becomes Larry's primary love interest for a time once he and Cheryl split up. Celebrities, including actors, comedians, authors, musicians and athletes, often make guest appearances on the show, with a large portion of them playing themselves, or fictional versions thereof.
Some of these guest stars are Mary Steenburgen, Mel Brooks, Michael York, Martin Scorsese, Ben Stiller, Martin Short, Lucy Lawless, David Schwimmer, Shaquille O'Neal, Rosie O'Donnell, Ricky Gervais, Michael J.
The show won the 2002 Golden Globe Award for Best Television Series – Musical or Comedy.