Underlying thyroid diseases and autoimmune diseases such as Thyroiditis, Systemic Lupus and Rheumatoid Arthritis can provoke Chronic Urticaria or even Urticarial Vasculitis (a variant in which the lesions tend not to fluctuate but lead to skin bruising).
Urticarial Vasculitis may be associated with a fever, bone pains and joint swelling (Schnitzler’s Syndrome).
All forms of urticaria may occur in association with deeper skin swelling or angioedema and equally, angioedema may occur in isolation with no apparent urticaria.
This depends on whether we release histamine into the skin (urticaria), deeper tissues (angioedema) or both.
Ordinarily spontaneous urticaria has two patterns – Acute Urticaria and Chronic Urticaria.